Epigenetic regulation during craniofacial development

THE SHULL LAB NOW OPEN! CLICK HERE

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THE SHULL LAB NOW OPEN! CLICK HERE 〰️ 

I am a developmental biologist interested in the function of chromatin remodelers and epigenetic regulators during key developmental processes.
My research program will uncover the complexity of temporal and spatial gene regulation during the formation of the craniofacial skeleton using both zebrafish and mouse models.

Alcain Blue (cartilage) and Alizarin Red (bone) stained zebrafish lower jaw structures

Alcain Blue (cartilage) and Alizarin Red (bone) stained mouse skull

3D reconstruction of uCT scans from an E18.5 mouse skull

Research Interests

During craniofacial development, complex gene regulatory networks and subsequent signaling cascades must be carefully regulated both spatially and temporally to orchestrate the formation of different tissues and organ systems. How are complex gene regulatory networks and signaling pathways precisely activated or repressed?

Publications

Shull LC, et al. PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development. 2022 Feb 15;149(4). doi: 10.1242/dev.200082. PMID: 35132438; PMCID: PMC8918787.

Shull LC, et al. The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development. Dev Biol. 2020 May 15;461(2):132-144. doi: 10.1016/j.ydbio.2020.02.006. PMID: 32044379; PMCID: PMC7198358.

Time lapse of developing cartilage structures in a zebrafish head